GEORGETOWN UNIV WASHINGTON DC LOMBARDI CANCER CENTER
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During the last contract year, our laboratory has made significant progress in understanding the genetics of the human major histocompatibility complex HLA. Ten new homozygous typing cells HTCs were identified, specific for known HLA-D region antigens. For each cell stored in our liquid nitrogen freezers, complete personal and genetic information is now maintained in a computer data bank. This facilitates easy access and inventory control. In collaboration with the Naval Medical Research Institute, a system using PHA-stimulated homozygous typing cells has been developed for rapid transplant matching. The technology for T-lymphocyte cloning has been extended and utilized to being analysis of D-region genetics in detail. This important technique has already begun to yield results which suggest the presence of D-region complexities derived from previously undefined specificities and new gene products. We have provisionally designated one such new locus TLC-A T-lymphocyte clone-A as the first of what may prove to be a long series of different loci linked to HLA genes.
- Medicine and Medical Research