An Examination of the Feasibility of Administering Prophylactic Pyridostigmine by the Percutaneous Route.
MATERIALS RESEARCH LABS ASCOT VALE (AUSTRALIA)
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The feasibility of administering pyridostigmine by the percutaneous route was examined by the use of guinea pigs in vivo and their skin in vitro. Pyridostigmine has a possible use as a prophylactic against poisoning by organophosphorus esters. The compound enters the animal to inhibit blood cholinesterase, producing effects observable in 30 minutes. Evidence of the storage of pyridostigmine in skin was found. The compound when crossing skin in vitro takes 1,000 minutes to reach an equilibrium rate. A permeability constant of .000002 cmmin was estimated. The main problem remaining is the practical one of making a dosage form suitable for presenting the pyridostigmine at constant concentration to the skin for a long period. Author