Chemical Research at the Institut fuer Strahlenchemie, Muelheim.
OFFICE OF NAVAL RESEARCH LONDON (ENGLAND)
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Described in this report are recent results from various research projects in progress at the institute. Schaffner and co-workers have been involved in a study of photochemical reactions of Beta, Gamma-unsaturated ketones. The photoisomerization of a bicyclo3.2.2nonanaphthalene yields a strained tricyclic semibullvalene type product. Catalytic reversal of this reaction in the dark can be effected at ambient temperature. Schaffner has pointed out that this cycle represents a model for chemical light energy storage. Schaffner has also been involved in a detailed study of the photophysical properties of biliverdin, a substrate closely related in structure to the plant photoreceptor, phytochrome. The chemistry of ethers and acetals under 60 Co Gamma-radiolysis and UV irradiation has been studied by Schulte-Frohlinde and von Sonntag. Kinetics of the reactions were monitored by pulse conductivity methods using electron pulses from a 2.8 MeV van de Graaff generator. Research by Nicolau on the use of vesicles to deliver inositol hexaphosphate IHP, an allosteric effector of hemoglobin, to red blood cells RBC may result in procedures for dramatically increasing the oxygen release capacity of RBC. Potential applications include an improved O2 supply to tissues under low O2-partial pressure in air such as at high altitudes. Preliminary experiments with rats have shown that incorporation of IHP into the RBC enables the rats to adapt to reduced O2 partial pressures.
- Organic Chemistry