Accession Number:

ADA098650

Title:

The Role of Electronically Excited States and Free Radicals in Ultraviolet-Induced Lens Opacification.

Descriptive Note:

Final rept. 15 Mar 78-15 Mar 79,

Corporate Author:

DUKE UNIV DURHAM NC DEPT OF ELECTRICAL ENGINEERING

Personal Author(s):

Report Date:

1980-12-01

Pagination or Media Count:

86.0

Abstract:

Ocular lens safety criteria with respect to UV radiation wavelength and dosage are outlined. These criteria are based on spectroscopic and biochemical studies of UV-exposed and control lenses as well as isolated lens proteins. Excited states of tryptophan in the lens crystallin proteins are implicated as the major species responsible for UV-induced cataractogenesis possible causal mechanisms including crosslinking of peptides are suggested. Author

Subject Categories:

  • Radiobiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE