The Role of Electronically Excited States and Free Radicals in Ultraviolet-Induced Lens Opacification.
Final rept. 15 Mar 78-15 Mar 79,
DUKE UNIV DURHAM NC DEPT OF ELECTRICAL ENGINEERING
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Ocular lens safety criteria with respect to UV radiation wavelength and dosage are outlined. These criteria are based on spectroscopic and biochemical studies of UV-exposed and control lenses as well as isolated lens proteins. Excited states of tryptophan in the lens crystallin proteins are implicated as the major species responsible for UV-induced cataractogenesis possible causal mechanisms including crosslinking of peptides are suggested. Author