Spontaneous Growth Hormone Release in Tethered Cynomolgus Monkeys.
ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD
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In order to determine spontaneous growth harmone GH release patterns in unsedated and unrestrained nonhuman primates a jacket and tethering system were used to study 6 cynomolgus monkeys. Hourly blood samples were collected and body temperatures recorded over 8- and 24-h periods. Measurements of GH, glucose, beta-hydroxybutyrate and free fatty acids FFA were made on all samples. Conclusions GH in unsedated, unrestrained cynomolgus monkeys was released in 4-5 h cycles without increased nighttime release. A brief period of self-feeding caused a lowering of GH concentration followed by a rebound increase. These changes could be eliminated by fasting. The tethering system allowed repeated sampling of blood and reading of temperature over extended periods of time without disturbing the monkeys and still allowed self-feeding, grooming and socializing.