Accession Number:

ADA091381

Title:

Histocompatibility Typing for the Prediction of Susceptibility to Infectious Disease.

Descriptive Note:

Technical rept.,

Corporate Author:

GEORGETOWN UNIV WASHINGTON DC LOMBARDI CANCER CENTER

Personal Author(s):

Report Date:

1980-06-01

Pagination or Media Count:

18.0

Abstract:

The objective of these studies is to determine if susceptibility to certain infectious agents or morbidity associated with infection can be predicted based on knowledge of HLA type. The studies will investigate if certain diseases or disease processes are associated with, or linked to, the HLA region genes. The format of these studies will follow guidelines which include careful disease classification or subclassification based on firm clinical and laboratory parameters preparation of data collection forms based on items to be included in the analysis collection and storage of cells HLA typing of sample population random populations exhibiting trait andor families and statistical analysis for association or linkage of HLA and disease parameter. The population chosen for the index study comprises individuals who as infants suffered respiratory syncytial virus RSV infection, where a small number developed bronchiolitis requiring hospitalization while most recovered with no severe side effects. Association andor linkage between HLA, virus infection seroconversion and morbidity bronchiolitis as well as a number of other factors will be evaluated within the random sample population and within families using standard statistical methods.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE