Redistribution of Zinc within Burned and Burned Infected Rats (40765)
ARMY INST OF SURGICAL RESEARCH FORT SAM HOUSTON TX
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Burns covering 30 or more of the total body surface place a severe metabolic demand on the host, a demand that often exceeds even that imposed by some infections. Though burns elicit alterations in amino acid, trace metal, and protein metabolism akin to those observed during infection, injury, and inflammation, there is a recent report by Oh et al. which indicates that burns might differ from other inflammatory stresses in that zinc does not accumulate in the liver despite a significant decrease in serum zinc. The absence of zinc sequestration by the liver in burned animals might be the result of leakage from the wound or a differential deposition within the wound itself. The latter possibility is intriguing in that, during myocardial infection, zinc appears to accumulate preferentially at the site of the damage in organelles associated with biosynthesis, and there is evidence that added zinc aids in wound healing in zinc deficient animals. Another reason to reinvestigate whether hepatic zinc accumulation occurs in burned animals is that hepatic zinc accumulation has always preceded or accompanied acute-phase globulin synthesis during inflammation and infection, even in zinc deficient animals. Since burned rats are known to exhibit increased synthesis of acute phase globulins, the absence of enhanced zinc uptake by the liver would indicate that this apparent association between zinc influx to the liver and increased acute-phase globulin synthesis is, indeed, merely coincidental and neither essential nor casual.
- Medicine and Medical Research