Accession Number:

ADA091340

Title:

Histamine Receptor Control of Gastric Microvasculature in Shock

Descriptive Note:

Journal article

Corporate Author:

ARMY INST OF SURGICAL RESEARCH FORT SAM HOUSTON TX

Report Date:

1979-01-01

Pagination or Media Count:

8.0

Abstract:

Control of gastric mucosal blood flow in hemorrhagic shock was investigated, in an anesthetized miniature swine model, using H sub 1 -receptor diphenhydramine and H sub 2 -receptor cimetidine antagonisms. The animals were divided into two experimental groups i diphenhydramine treatment and ii diphenhydramine plus cimetidine treatment. Results were compared to previously reported untreated controls and animals who received cimetidine alone. Conclusions reached were 1 Histamine receptors in the gastric microvasculature do play a role in the control of mucosal blood flow during shock. 2 H sub 2 -Receptor antagonism, whether alone or in conjunction with H sub 1 -receptor antagonism, results in significant protection against a shock-related decrease in gastric mucosal blood flow. 3 H sub 1 -Receptor antagonism does not affect gastric mucosal blood flow in shock.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE