Recovery of Monkeys After Myocardial Infarction with Ventricular Fibrillation. Effects of PGB
HAHNEMANN MEDICAL COLL AND HOSPITAL PHILADELPHIA PA DEPT OF PHYSIOLOGY AND BIOPHYSICS
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PGB sub x, a polymeric, stable, free radical derivative of 15-keto-prostaglandin B sub 1, that conserves oxidative phosphorylation in mitochondria under degenerative conditions in vitro, affected survival of male Rhesus monkeys 5-9 kg anesthetized with pentobarbital and subjected to coronary ligation and induced ventricular fibrillation VF. In tests performed in sequence with intervening periods for recovery, intracardiac injections of norepinephrine NE, cardiac massage cm, and electrical defibrillation EDF were used to restore cardiac function both in controls and experimental animals, but the latter were injected also with 1 mgkg PGB sub x. Recovery was established by maintenance of effective blood pressure without exogenous support. In the control group the cumulative survival for fibrillation episodes of 4, 6, 8, and 12 min was 60, 40, 31, and 25 respectively. In the PGB sub x-treated group survival for equivalent periods was 100, 93, 93, and 88 respectively. In separate studies, African Green monkeys were subjected to single episodes of VF of either 8 or 12 min. Combined survival was 36 for the controls, 93 for the PGB sub x-treated animals. Clearly PGB sub x radically improved cardiac recovery after circulatory arrest due to VF in the presence of acute myocardial infarction. The results also suggest a synergistic action between norepinephrine and PGB sub x in achieving such recovery.
- Anatomy and Physiology
- Medicine and Medical Research