Accession Number:

ADA091047

Title:

Mechanisms of Microwave-Induced Blood-Brain Barrier Alterations.

Descriptive Note:

Final rept. 1 Apr 78-31 Aug 80,

Corporate Author:

WAYNE STATE UNIV DETROIT MI DEPT OF ELECTRICAL AND COMPUTER ENGINEERING

Personal Author(s):

Report Date:

1980-09-01

Pagination or Media Count:

31.0

Abstract:

This investigation was designed to study the mechanisms of interaction between microwaves and the blood-brain barrier and was aimed at correlating changes of blood-brain barrier permeability with the quantity and distribution of absorbed microwave energy inside the brain of adult Wistar rats under sodium pentobarbital anesthesia. Through use of thermographic methods and a direct-contact applicator at the animals head, the pattern of absorbed microwave energy was determined. Indwelling catheters were placed in the femoral vein. Evans blue in isotonic saline were used as a visual indicator of barrier permeation. Irradiation with pulsed 2450-MHz microwaves for 20 min at average power densities of 0.5 to 2600 mWsquared, which resulted in average specific absorption rates SARs of 0.04, to 200 mWg in the brain, did not produce staining, except in regions that normally are highly permeable. When the incident power density was increased to 3000 mWsquared SAR of 240 mWg, extravasation of Evans blue could be seen in the cortex, hippocampus and midbrain.

Subject Categories:

  • Stress Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE