Accession Number:

ADA090912

Title:

Modification of Lethality Induced by Staphylococcal Enterotoxin B in Dutch Rabbits

Descriptive Note:

Journal article

Corporate Author:

ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD

Personal Author(s):

• Liu, C. T.
• Sanders, R. P.

Report Date:

1980-03-01

Pagination or Media Count:

6.0

Abstract:

Intramuscular injection of staphylococcal enterotoxin B SEB at a dosage level of 50 microgramskg of body weight caused death in Dutch rabbits. Lethality was not modified markedly by morphine pretreatment or by hyperthermia, thyrotoxicosis, propylthiouracil feeding, thyroparathydroidectomy, water deprivation, or fasting. The administration of acetylsalicylic acid to the SEB-inoculated rabbit also failed to protect the rabbits from the effect of SEB. Seemingly, the SEB molecular destruction was not markedly modified by alteration of cellular metabolism, and lethal effects of SEB remained unchanged in the morphine- or acetylsalicylic acid-treated rabbits. When SEB was given to six rabbits 3 days after total-body X-irradiation, fewer persisted and three rabbits survived. An identical dose of SEB to nonirradiated rabbits produced fever initially, followed by hypothermia and death of all rabbits.

Descriptors:

• *BACTERIAL TOXINS
• *ENTEROTOXINS
• *STAPHYLOCOCCUS
• LETHAL DOSAGE
• LETHALITY
• MORPHINE
• RABBITS
• REPRINTS
• SALICYLIC ACIDS
• WHOLE BODY IRRADIATION
• X RAYS

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE