Accession Number:

ADA090679

Title:

Neuropharmacology and Therapeutics of AF Chemicals

Descriptive Note:

Annual rept. 1 Feb 1979-31 Jan 1980

Corporate Author:

CALIFORNIA UNIV LOS ANGELES SCHOOL OF MEDICINE

Personal Author(s):

• Sterman, M. B.
• Shouse, M. N.
• Fairchild, M. D.

Report Date:

1980-08-01

Pagination or Media Count:

19.0

Abstract:

In a continuing evaluation of mechanisms underlying convulsions produced by monomethylhydrazine MMH we have attempted to compare this response to seizures produced by a non-toxic, chronic experimental model of current interest in epilepsy kindling. A series of studies were directed towards a comparison of seizure susceptibility, the protective effects of pyridozine and the therapeutic effects of thalamic lesions on both models. A significant correlation was obtained between MMH seizure latencies and initial afterdischarge thresholds for kindling in the same animals. Moreover, pyridoxine provided substantial protection against MMH seizures and a slight but consistent elevation of seizure thresholds with the kindling model. Finally lateral thalamic lesions significantly reduced seizure susceptibility with both models. The physiological and therapeutic implications of these findings are discussed.

Descriptors:

• *METHYL HYDRAZINES
• *LESIONS
• *CONVULSIVE DISORDERS
• *PYRIDOXINES
• TIME INTERVALS
• STIMULATION(PHYSIOLOGY)
• LABORATORY TESTS
• PSYCHOMOTOR FUNCTION
• DOSAGE
• EPILEPSY
• THALAMUS
• CATS
• CEREBRAL CORTEX
• PHARMACOLOGICAL ANTAGONISTS
• PROTECTION
• THERAPY
• EXPOSURE(PHYSIOLOGY)
• NEUROLOGY
• THRESHOLDS(PHYSIOLOGY)

Subject Categories:

• Medicine and Medical Research
• Chemical, Biological and Radiological Warfare

Distribution Statement:

APPROVED FOR PUBLIC RELEASE