Accession Number:

ADA090403

Title:

The Role of Endorphins in the Pathophysiology of Shock and the Therapeutic Benefit of Opiate Antagonists,

Descriptive Note:

Corporate Author:

WALTER REED ARMY INST OF RESEARCH WASHINGTON DC

Personal Author(s):

• Holaday,John W.
• Faden,Alan I.

Report Date:

1980-06-01

Pagination or Media Count:

14.0

Abstract:

Evidence is presented that the pure opiate antagonist naloxone rapidly increases blood pressure and decreases mortality associated with shock caused by endotoxemia, hemorrhage, and spinal-cord transection. Shock studies conducted in rats, cats, and dogs demonstrate these therapeutic effects of naloxone across a variety of species. Additionally, naloxone treatment significantly improves neurologic recovery paralysis after spinal-cord injury in the cat. Results from additional experiments provide evidence for the site and mechanisms of these therapeutic effects of naloxone.

Descriptors:

• *DRUGS
• *PHARMACOLOGICAL ANTAGONISTS
• *NARCOTICS
• STABILIZATION
• RATS
• THERAPY
• DOGS
• SHOCK(PATHOLOGY)
• BLOOD PRESSURE
• OPIUM ALKALOIDS
• CATS

Subject Categories:

• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE