Accession Number:

ADA090358

Title:

Pattern Recognition Applications in Chemistry and Pharmacology: A 'Pharmacophore Acetylcholinoreceptor' Subunit Environment Model,

Descriptive Note:

Corporate Author:

ARMY ARMAMENT RESEARCH AND DEVELOPMENT COMMAND ABERDEEN PROVING GROUND MD CHEMICAL SYSTEMS LAB

Personal Author(s):

• Ashman,William P.
• Thornton,William
• Broome,Paul H.
• King,James W.
• Sacco,William J.

Report Date:

1980-06-01

Pagination or Media Count:

15.0

Abstract:

In the analysis of a compounds structure for the prediction of its resultant pharmacological activity, the ultimate goal of the researcher is the explanation of the physiological mechanisms and compound interactions involved from the moment the drug is administered until the time it completes its effect. Having this knowledge, the researcher can then design compounds producing the efficacious-ness desired. With this objective, investigators at the Research Division, Chemical Systems Laboratory, APG, MD have conducted chemical structure-biological activity relationship SAR studies 1 on various classes of compounds whose pharmacological actions in vivo are directly related to the cholinergic system. The studies have included toxicity, cholinolytic and cholinomimetic activity, and the medicalprophylactic andor therapeutic efficacy of compounds or mixtures of compounds against anticholinesterase poisoning. Author

Descriptors:

• *PATTERN RECOGNITION
• *DRUGS
• *PHARMACOLOGY
• MODELS
• TOXICITY
• PHYSIOLOGICAL EFFECTS
• MOLECULAR STRUCTURE
• CHOLINESTERASE INHIBITORS
• CHEMOTHERAPY

Subject Categories:

• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE