Host Defense against Opportunist Microorganisms Following Trauma.
Annual summary rept. 1 Jul 78-30 Jun 79,
CINCINNATI UNIV OH COLL OF MEDICINE
Pagination or Media Count:
Studies were performed to evaluate selected humoral components of host defense in 4 septic and 6 non-septic burned patients during 60 days postburn. The parameters measured in all patients were total hemolytic complement CH50, C3 conversion by inulin and cobra venom factor CoVF, and immunochemical concentrations fo Clq, C4, C2, C3, C5, factor B, properdin, and C3b inactivator C3bINA. Ch50 and Clq were decreased in the sera of the septic burned patients during the first 10 days postburn, but were restored to normal thereafter. CH50 and Clq were normal or elevated in the sera of the non-septic burned patients for the duration of the study. Concentrations of C4, C2, C3 and C5 in the sera of all the patients were normal or elevated for the entire study period. C3 conversion by inulin and CoVF and the concentration of properdin were reduced in the sera of the septic and non-septic burned patients for the duration of the study, and concentrations of factor B and C3bINA were normal or elevated. When the non-septic burned patients were subdivided by the presence or absence of transient bacteremia, no significant difference in concentrations or functional activity of components of the classical or alternative complement pathways was demonstrated.
- Medicine and Medical Research