Animal Studies in PGBx.
Final technical rept. 1 Mar 77-31 Dec 79,
HAHNEMANN MEDICAL COLL AND HOSPITAL PHILADELPHIA PA DEPT OF PHYSIOLOGY AND BIOPHYSICS
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The effects of PGBx, a newly synthesized polymeric derivative of 15-keto-prostaglandin B1, were tested in a number of experimental studies in monkeys, dogs and other species. Treatment with PGBx was found to markedly improve survival after a period of complete circulatory arrest and to restore cardiac function in monkeys and dogs. Pilot studies in attempts to develop a simpler animal or isolated organ test system for PGBx did not yield positive results. PGBx has no effect on normal tissues or organs but appears to have unique properties in restoring biological activity following tissue hypoxia or ischemia. Entirely novel experimental approaches are therefore needed to provide the appropriate and critical conditions for demonstrating and quantitating its biological activity. Author
- Medicine and Medical Research