Accession Number:

ADA083642

Title:

Carcinogenic Potential of Cholesterol Oxidation Products

Descriptive Note:

Final rept. 1 Feb 1977-31 Jan 1980

Corporate Author:

BROWN UNIV PROVIDENCE RI

Personal Author(s):

Report Date:

1980-04-15

Pagination or Media Count:

7.0

Abstract:

In a pilot experiment we found striking indication that the inclusion in the diet of a dehydrated egg and milk powder, which is produced for human consumption, induced a high incidence of liver tumors in mice. We postulated that the carcinogens might be oxidation products of cholesterol. Subsequent pilot experiments revealed an increase in the incidence of liver tumors after brief inclusion in the diet of 1.0 5,6-epoxide of cholesterol, but not after prolonged inclusion of 0.1 3,5,6-trihydroxycholesterol.

Subject Categories:

  • Medicine and Medical Research
  • Food, Food Service and Nutrition

Distribution Statement:

APPROVED FOR PUBLIC RELEASE