Carcinogenic Potential of Cholesterol Oxidation Products
Final rept. 1 Feb 1977-31 Jan 1980
BROWN UNIV PROVIDENCE RI
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In a pilot experiment we found striking indication that the inclusion in the diet of a dehydrated egg and milk powder, which is produced for human consumption, induced a high incidence of liver tumors in mice. We postulated that the carcinogens might be oxidation products of cholesterol. Subsequent pilot experiments revealed an increase in the incidence of liver tumors after brief inclusion in the diet of 1.0 5,6-epoxide of cholesterol, but not after prolonged inclusion of 0.1 3,5,6-trihydroxycholesterol.
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