Sensitivity of Selected Arenaviruses to a Human Interferon.
ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FREDERICK MD
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Assessment of arenavirus sensitivities to an interferon IF of human cell culture origin was accomplished by a plaque reduction PR50 method in cells of monkey BS-C-1 and human origin Detroit 532. Arenavirus sensitivity to the human IF was compared in parallel titrations to the IF sensitivity of vesicular stomatitis virus VSV. Interferon bioassays in both cell types indicated that all arenavirus members were less sensitive to IF of human origin than was the standard challenge virus, VSV. Bioassay of human IF on BS-C-1 cells provided a wider spectrum of interferon sensitivity among the various arenavirus members than that shown for Detroit 532 cells. There was no apparent correlation between human IF sensitivity and human virulence with the arenaviruses tested. Author
- Medicine and Medical Research