Ribavirin Treatment of Toga-, Arena- and Bunyavirus Infections in Subhuman Primates and Other Laboratory Animal Species
ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD
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Ribavirin was effective in reducing viremia and increasing the number of survivors compared to untreated monkeys infected with Rift Valley fever a bunyavirus, Lassa or Machupo both arenaviruses viruses. Treatment was effective when given initially at the time of virus inoculation or later, after the onset of viremia and fever. Only minimal effect was evident against yellow fever virus a flavivirus infection in rhesus monkeys, even when treatment was initiated within 8 hours after virus inoculation. Ribavirin was ineffective against Chikungunya virus an alphavirus infection of monkeys. The apparent inability of ribavirin to achieve effective concentrations in the central nervous system may limit its usefulness against viruses causing primary encephalitis.
- Medicine and Medical Research