Accession Number:

ADA080146

Title:

Mammalian Toxicity of Munitions Compounds. Summary of Toxicity of Nitrotoluenes

Descriptive Note:

Progress rept. no. 11, 1 Apr 74-31 Aug 78

Corporate Author:

MIDWEST RESEARCH INST KANSAS CITY MO

Report Date:

1980-01-01

Pagination or Media Count:

51.0

Abstract:

This report is a summary of all findings on nitrotoluene derivatives done in the course of the contract. It incorporates portions of Progress Reports Nos. 1, 3, 4, 6 and 7, as well as overall comparisons and conclusions. Acute toxicity data, including rodent LD50s, rabbit irritation tests, guinea pig dermal sensitization test, single-dose metabolism study in rats, and the Ames Salmonellamicrosome test were done on 2,4,6-trinitrotoluene, all dinitrotoluene DNT isomers 2,3-, 2,4-, 2,5-, 2,6-, 3,4-, and 3,5- and except for the metabolisms study and Ames test 2-amino-4, 6-dinitrotoluene and 4-amino-2, 6- dinitrotoluene.. Subchronic toxicity tests were done with 2,4-DNT and 2,6-DNT in dogs, rats and mice. Chronic toxicity tests were done with 2,4-DNT in all three species, accompanied by reproductive studies in rats. The metabolism of 2,4-DNT was studied in rats after chronic feeding of 2,4-DNT and in mice, rabbits, dogs, monkeys and in vitro preparations in single-dose studies. Author

Subject Categories:

  • Toxicology
  • Ammunition and Explosives

Distribution Statement:

APPROVED FOR PUBLIC RELEASE