Chemotherapeutic Studies on Schistosomiasis.
Annual technical rept. no. 5, Oct 77-Sep 78,
BRASILIA UNIV (BRAZIL)
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The collaborative antischistosome drug testing program between the University of Brasilia and the U.S. Army Medical Research Unit WRAIR Brasilia continues to screen new chemical compounds for prophylactic and curative activity against shcistosomiasis mansoni. The Primary Mortality Test PMT is a prophylactic test system which uses mice exposed to 3,000 or more S. mansoni cercariae. The laboratory Biomphalaria glabrata snail colony supported a daily inventory of 1,000 to 1,200 S. mansoni infected snails. The weekly cercarial collections of three to five million were more than adequate to infect prophylactic test group mice with 3,000 or more cercariae each. A total of 1,195 drugs were tested for prophylactic andor curative activity of these drugs 538 were tested in the PMT, 218 of these being confirmatory retests. Results of prophylactic testing were 396 drugs negative or unconfirmed active 136 drugs toxic 6 drugs confirmed active.
- Medicine and Medical Research