Behavioral Effects of Acute Aerosol Exposure to N, N-Diethy-Meta-toluamide (M-Det), January - February 1979
Toxicological assessment program study rept.
ARMY ENVIRONMENTAL HYGIENE AGENCY ABERDEEN PROVING GROUND MD
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Groups of 10 male and 10 female rats were exposed for single 4-hour periods to aerosols of M-Det an insect repellent at concentrations estimated to be 1 high enough to produce minimal toxic signs 4100 mgcu m 2 too low to produce toxic signs 2900 mgcw m or 3 somewhat lower 2300 mgcu m. Concommitant controls were exposed to chamber air only. The rats were given a battery of behavioral tests as soon as the exposure period ended. The results of the battery permitted distinctions to be made between performance at all three levels and controls for both males and females. Tests included measures of activity, endurance, balance, tactical sensitivity, post exposure learning, and memory of a task learned the day before exposure. Necropsy did not show any gross physical changes as a result of the exposures. Thus, behavioral tests were able to establish changes resulting from acute exposures to M-Det at concentrations below those at which toxic signs could be detected.