Accession Number:

ADA073750

Title:

Effect of Anti-Parasite Chemotherapeutic Agents on Immune Reactions.

Descriptive Note:

Rept. no. 1 (Annual),

Corporate Author:

SOUTH CAROLINA UNIV COLUMBIA

Personal Author(s):

Report Date:

1979-08-29

Pagination or Media Count:

14.0

Abstract:

Five agents, namely chloroquine phosphate WR 1544, primaquine phosphate WR 2975, quinine sulphate WR 2976-5, quinine dihydrochloride monohydrate WR 2976-HCl, and 1-1,3-dichloro-6-trifluoromethyl-9-phenanthryl-3-di-n-butylamminopropanol hydrochloride DTPA WR 171669, were studied for their effect on humoral response to sheep erythrocytes SRBC as measured by the plaque-forming cell PFC contents of spleens, delayed hypersensitivity DH reaction to SRBC, and phagocytic activity were studies in mice. Humoral PFC responses were not affected by WR 1544 or WR 2975. Quinine sulphate WR 2976-S and quinine dihydrochloride monohydrate WR 2976-HCl suppressed PFC responses when injected one day before, but enhanced these responses when injected one day after the antigen. the DH reactions were not affected significantly by any of the drugs except WR 1544 at the higher dose 100 mgkg injected one day post antigen. Phagocytic activity was depressed by the high dose 100 mgkg of WR 1544, WR 2975, both low and high doses 40 and 160 mgkg0 of WR 2976-S and by the high dose of compounds WR 171669.

Subject Categories:

  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE