Effects of Ketamine, Xylazine, and Xylazine-Ketamine Combination on EEG Activity in Rabbits.
AEROSPACE MEDICAL RESEARCH LAB WRIGHT-PATTERSON AFB OH
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Xylazine followed in 10 minutes with ketamine HCl was found to be a safe, effective anesthetic combination in New Zealand White rabbits. Dosages of 8.8 mgkg xylazine followed by 40 mgkg ketamine produced light anesthesiaanalgesia of approximately 45 minutes duration dosages at the 9.9 mgkg and 50 mgkg level produced surgical anesthesia for approximately 75 minutes. EEGs, pain response, heart rates and rectal temperatures were monitored with both dose regimes and during several surgical procedures laparotomy, toe amputation. The EEG activity was used to analyze the trend and level of anesthesia. Statistics of EEG activity during the preinjection, anesthesia and recovery periods were calculated. Changes in EEG are most prominent one to two minutes after administration of ketamine. At this time there is a large increase in the level of delta activity and a corresponding decrease in the alpha and beta activity. Heart rates decreased following xylazine and ketamine injections. Temperatures were noted to decrease with both combinations of these drugs. Pentobarbital anesthesia was similarly monitored for comparison variable effects were observed.