Accession Number:

ADA071655

Title:

A System for Exposure of Rats and Mice to Aerosols of Plutonium Oxide. Design and Construcction of an Exposure Suite for Mice,

Descriptive Note:

Corporate Author:

ATOMIC ENERGY RESEARCH ESTABLISHMENT HARWELL (ENGLAND)

Personal Author(s):

• Walsh,M.
• Black,A.
• Moores,S. R.
• Pritchard,J.

Report Date:

1979-02-01

Pagination or Media Count:

24.0

Abstract:

Studies are being made to investigate the early and late pathological effects of plutonium oxide deposited in the rodent lung and their dependence on particle size and dose. The primary design consideration was the safety of personnel involved in the experiments and consequently all operations associated with animal exposures are carried out in glove boxes under carefully controlled conditions. This has placed restraints upon the manner in which these operations are performed. Thus, equipment has been designed to operate under these conditions and to minimise the possibility of an accidental exposure to plutonium oxide.

Descriptors:

• *AEROSOLS
• *OXIDES
• *PLUTONIUM COMPOUNDS
• PARTICLE SIZE
• RATS
• DOSAGE
• LUNG
• PATHOLOGY
• MICE

Subject Categories:

• Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE