Studies on Plasma Soluble Fluorescent Melanins.
Final rept. 1 Sep 78-30 Apr 79,
NORTHEASTERN UNIV BOSTON MA DEPT OF MEDICINAL CHEMISTRY AND PHARMACOLOG
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Plasma soluble fluroescent compounds termed rheomelanins have been isolated using paper chromatography. The fluorescent characteristic of these compounds ally them with tissue lipofuscins. Chemical composition studies using modified tissue lipofuscin histochemical tests were conducted. In addition, protein and lipid determination tests were done. All of these tests seem to indicate a strong relationship with the lipofuscins. Further experiments and investigations on the structure and content of these compounds are necessary. Author