The Efficacy of Therapy at Doses Suggested for Self-Aid against GD Poisoning.
DEFENCE RESEARCH ESTABLISHMENT SUFFIELD RALSTON (ALBERTA)
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Monkeys were exposed to 1 LD50 of GD and treated with a combination of clonazepam, atropine and toxogonin at doses suggested for self-aid. The doses used were based on equivalent human doses of 2 mgman of atropine, 5 mgman of clonazepam and 280 mgman of toxogonin. This therapy, given by intramuscular injection when the initial signs of poisoning occurred, adequately suppressed the abnormal EEG and muscular activity. Atropine reversed cardiac arrhythymia, but the GD-induced respiratory depression and bradycardia appeared more resistant and in some animals additional atropien was necessary. Control animals that only received therapy did not appear to be incapacitated. The results of this study suggest that this therapy would produce a degree of protection against GD poisoning and could be used as self-aid. Author