Accession Number:

ADA070589

Title:

Human Platelet Senescence.

Descriptive Note:

Annual rept. no. 8, 1 May 76-30 Jun 77,

Corporate Author:

NEW YORK UNIV MEDICAL CENTER N Y

Personal Author(s):

Report Date:

1978-07-18

Pagination or Media Count:

20.0

Abstract:

Evidence that large-heavy platelets megathrombocytes are released early from the bone marrow and become smaller-lighter platelets with time under basal conditions. Heterogeneity of platelet protein content as determined by SDS-polyacrylamide gel electrophoresis of cell sap proteins of various platelet populations isolated by differential centrifugation in plasma. Heterogeneity of platelet monoamine oxidase activity correlation with platelet protein density. Evidence that megathrombocyte number determines platelet function and that significant numbers of megathrombocytes are routinely discarded by conventional methods of preparation of platelet-rich plasma. Evidence that intact microtubules are required for platelet aggregation.

Subject Categories:

  • Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE