Accession Number:

ADA070467

Title:

Synthesis of C-5 Substituted Tubercidin Derivatives.

Descriptive Note:

Annual progress rept. 1 Feb 78-31 Jan 79,

Corporate Author:

CALIFORNIA UNIV DAVIS

Report Date:

1979-02-01

Pagination or Media Count:

22.0

Abstract:

Methodology for the synthesis of tubercidin derivatives substituted by carbon chains at the C-5 position has been developed. 5-Mercuritubercidin, prepared by reaction of tubercidin with mercuric acetate in water, undergoes coupling to olefins when treated with lithium palladium chloride in either methanol or N,N-dimethylformamide. In this way 5-1-methoxyethly tubercidin was prepared from ethylene, 5-2-cyanoethenyltubercidin from acrylonitrile, 5-2-carboxamido-ethenyltubercidin from acrylamide, and 5-2-methoxycarbonylethenyl tubercidin from methyl acrylate. Various synthetic transformations of these tubercidin derivatives were investigated.

Subject Categories:

  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE