Chemotherapy of Rodent Malaria Evaluation of Drug Action against Normal and Resistant Strains, Including Exo-erythrocytic Stages
Final rept. 1 Jan-31 Dec 1978
LIVERPOOL SCHOOL OF TROPICAL MEDICINE (UNITED KINGDOM) DEPT OF PARASITOLOGY
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Blood schizontocidal action of 5 WRAIR compounds and tissue schizontocidal action of 33 WRAIR compounds is summarised in this report. WR 226296 and WR 232584 and WR 235485, five-substituted 8-aminoquinolines, are highly active blood schizontocides. WR 235485 was active against chloroquine resistant lines but inactive against a primaquine resistant line. Of the 8- aminoquinolines tested WR221527 is the most active tissue schizontocide but does not possess residual action. A procedure has been developed in conjunction with WHO for the screening of blood and tissue schizontocides with prolonged activity. Details of the Screening procedure are included with this report. A fluorescent technique is being developed to identify long acting compounds which possess tissue schizontocidal activity. Investigations of polymer matrix preparations to prolong the antimalarial activity of pyrimethamine and sulphadiazine continue. A more reliable and technologically simpler method of preparing the drug-matrix polymers has been developed. Further studies on the mode of action of chloroquine are reported.