Accession Number:

ADA070345

Title:

Chemotherapy of Rodent Malaria Evaluation of Drug Action against Normal and Resistant Strains, Including Exo-erythrocytic Stages

Descriptive Note:

Final rept. 1 Jan-31 Dec 1978

Corporate Author:

LIVERPOOL SCHOOL OF TROPICAL MEDICINE (UNITED KINGDOM) DEPT OF PARASITOLOGY

Personal Author(s):

Report Date:

1978-12-01

Pagination or Media Count:

96.0

Abstract:

Blood schizontocidal action of 5 WRAIR compounds and tissue schizontocidal action of 33 WRAIR compounds is summarised in this report. WR 226296 and WR 232584 and WR 235485, five-substituted 8-aminoquinolines, are highly active blood schizontocides. WR 235485 was active against chloroquine resistant lines but inactive against a primaquine resistant line. Of the 8- aminoquinolines tested WR221527 is the most active tissue schizontocide but does not possess residual action. A procedure has been developed in conjunction with WHO for the screening of blood and tissue schizontocides with prolonged activity. Details of the Screening procedure are included with this report. A fluorescent technique is being developed to identify long acting compounds which possess tissue schizontocidal activity. Investigations of polymer matrix preparations to prolong the antimalarial activity of pyrimethamine and sulphadiazine continue. A more reliable and technologically simpler method of preparing the drug-matrix polymers has been developed. Further studies on the mode of action of chloroquine are reported.

Subject Categories:

  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE