Composition of Cerebral Fluids in Goats Adapted to High Altitude,
ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA
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The ionic composition of cerebral ISF was explored in 6 unanesthetized goats at sea level SL and again after 5 days at simulated high altitude HA of 4300 m, by measuring net transependymal fluxes of HCO3 ion, Cl ion and lactate during ventriculo-cisternal perfusions with lactate-free artificial CSF with various HCO3 ion and Cl ion concentration of an ion in cerebral ISF is indicated by concentration of that ion in the inflowing perfusate, that produces zero flux. We conclude that, at SL, HCO3 ion and Cl ion in CSF were the same as in cerebral ISF, which is in agreement with previously published findings. In goats adapted to HA, Cl ion in cerebral ISF remained equal to Cl ion in CSF, while HCO3 ion in cerebral ISF was demonstrably lower, and lactate presumably higher, than in CSF. The fluid surrounding the central chemoreceptors appears to be more acidic in goats acclimatized to HA than at SL, in spite of the alkalosis in cisternal CSF. This may contribute to ventilatory acclimatization to HA.
- Anatomy and Physiology