Accession Number:

ADA070026

Title:

Mechanisms of Oxygen Toxicity at the Cellular Level,

Descriptive Note:

Corporate Author:

MISSOURI UNIV-COLUMBIA JOHN M DALTON RESEARCH CENTER

Report Date:

1978-01-01

Pagination or Media Count:

16.0

Abstract:

Oxygen at elevated pressures is toxic for life forms from microbes to man. Growth is inhibited in Escherichia coli and results primarily from poisoning of specific enzymes in the following biosynthetic pathways branched-chain and aromatic amino acids, NAD-niacin, phosphoribosylpyrosphosphate PRPP and reverse glycolysis. Inhibition of amino acid biosynthesis indirectly stops protein synthesis and induces stringency production of pp-guainine-pp, a powerful inhibitor of metabolic processes which accounts for inhibition in metabolic processes where there is no observed enzymatic poisoning. Inhibitions in the PRPP, NAD-niacin, and reverse glycolysis pathways are significant to bacterial and perhaps to human oxygen toxicity where products of the pathways protect. Author

Subject Categories:

  • Biochemistry
  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE