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Accession Number:
ADA067890
Title:
Studies of Altered Response to Infection Induced by Thermal Injury.
Descriptive Note:
Annual progress rept. 1 Jan-31 Dec 78,
Corporate Author:
CALIFORNIA UNIV SAN FRANCISCO
Report Date:
1979-01-31
Pagination or Media Count:
32.0
Abstract:
This report describes the results of this years experiments to reduce the post burn incidence of fatal sepsis by 1 rapidly identifying and segregating those individuals that are at greatest risk of sepsis 2 delineating the nature of the burn induced immune defect and 3 characterizing those mechanisms by which thermal injury causes immune aberrations. Understanding of these mechanisms may allow development of far forward prophylactic measures which could prevent thermal injury from inducing immune defects. Experimental data derived from our patient studies have allowed us to develop assays for detecting early immune anomalies and to delineate the cell types involved in these aberrations. Our murine model has been primarily utilized to characterize the mechanisms by which thermal injury causes the development of immune defects. The most pertinent results from this years research can be summarized as follows Those thermally injured individuals who will be unable to contain an infectious challenge have leukocytes which are PHA hyporesponsive beginning at days 4-6 post burn. All other thermally injured patients have unchanged or hyper-responsive leukocytes in the PHA assay. 85 percent of the burn patients whose lymphocytes were hyporesponsive in the PHA assay later succumbed to septicemia.
Distribution Statement:
APPROVED FOR PUBLIC RELEASE
