Accession Number:

ADA067169

Title:

Effect of Ribavirin Given in Small-Particle Aerosols on Selected Clinical and Hematological Responses.

Descriptive Note:

Interim rept.,

Corporate Author:

ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FREDERICK MD

Personal Author(s):

• Berendt,R. F.
• Stephen,Edward L.

Report Date:

1979-02-08

Pagination or Media Count:

13.0

Abstract:

The effect of 40 mgkgday of ribavirin given for 4 days by aerosol to squirrel monkeys was compared to 40 and 400 mgkg orally and to additional monkeys given water by the aerosol or oral route. Suppression of erythrocyte and hemoglobin levels occurred with the high oral dose, and all groups of ribavirin-treated monkeys had some dyspnea and lethargy. In view of these transient effects short courses of ribavirin may be administered safely. Author

Descriptors:

• *TOXICITY
• *ANTIVIRAL AGENTS
• AEROSOLS
• MICE
• INFLUENZA VIRUS
• CHEMOTHERAPY
• HEMATOLOGY
• SQUIRREL MONKEYS

Subject Categories:

• Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE