Accession Number:

ADA066953

Title:

Response of Combined Electrical Stimulation and Biodegradable Ceramics.

Descriptive Note:

Annual rept. no. 3,

Corporate Author:

ALABAMA UNIV IN BIRMINGHAM

Personal Author(s):

Report Date:

1978-03-01

Pagination or Media Count:

34.0

Abstract:

Investigations on the surgical correction of nonunion lesions in rabbit tibias with rod form porous tricalcium phosphate ceramics extended from one to nineteen months. Combinations of porous implant and iliac crest autogeneous bone grafts were included. Granular form tricalcium phosphate and autogeneous bone combinations were studied for segmental replacements in rabbit tibias while rod form segmental implants were placed in dog radii. Radiographic, general clinical, necropsy, histologic and metabolic methods were used to evaluate the experimental animals. Rod forms of porous tricalcium phosphate ceramic implanted at nonunion sites in rabbit tibias showed a low probability for correction in that only two of twenty obtained a bony union. A combination of rod forms and iliac crest autogeneous bone showed clinical union for ten out of twelve nonunions. Mixtures of granular tricalcium phosphate ceramic and autogeneous bone for segmental bone lesion correction in the rabbit tibia showed a dependence on the relative quantity of materials in the implant mixture. Segmental bone replacements at the mid shaft positions of dog radii showed that internal fixation could be utilized and the site provides opportunities for long-term studies. Gross and histological evaluations of implant sites and major organs in rabbits showed good biocompatibility for tricalcium phosphate ceramic implants. Investigations are continuing. Author

Subject Categories:

  • Medicine and Medical Research
  • Ceramics, Refractories and Glass

Distribution Statement:

APPROVED FOR PUBLIC RELEASE