Accession Number:

ADA066948

Title:

Changes in CNS Metabolism in High Pressure Nervous Syndrome, High Pressure Narcosis, and Methods of Protection.

Descriptive Note:

Final rept. 1 Oct 74-31 Dec 77,

Corporate Author:

DUKE UNIV MEDICAL CENTER DURHAM N C DIV OF RADIOBIOLOGY

Personal Author(s):

• Sanders,Aaron P.
• Currie,William D.

Report Date:

1977-12-31

Pagination or Media Count:

13.0

Abstract:

Our initial approach to the study of mechanisms of acute central nervous system high pressure toxicity was to study enzyme activities and concentrations of the series of metabolites which have been shown to provide protection against O2 toxicity during air and hyperbaric oxygen exposures - 5 ATA O2 - 11 ATA O2, with or without exogenous administration of the particular protective agent.

Descriptors:

• *ENZYMES
• *CENTRAL NERVOUS SYSTEM
• *NARCOSIS
• TOXICITY
• HIGH PRESSURE
• METABOLISM
• OXYGEN
• PROTECTION
• METABOLITES
• HYPERBARIC CONDITIONS

Subject Categories:

• Biochemistry
• Medicine and Medical Research
• Stress Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE