Accession Number:

ADA065776

Title:

Immunologic Interrelationships of Coliform Heat-Labile and Heat-Stable Enterotoxins

Descriptive Note:

Rept. no. 7 (Annual) 15 Feb 1978-15 Jan 1979

Corporate Author:

ROCHESTER UNIV NY SCHOOL OF MEDICINE AND DENTISTRY

Personal Author(s):

Report Date:

1979-01-15

Pagination or Media Count:

12.0

Abstract:

The goal of these studies is the development of an immunization program to prevent diarrheal disease due to intestinal contamination by enterotoxigenic strains of coliform bacteria. We have demonstrated that a active immunization with a purified preparation of the polymyxin release form of Escherichia coli heat-labile enterotoxin yields protection against strains of this bacteria which produce this form of toxin b the use of cimetidine renders the peroral route of immunization effective and c peroral, but not parenteral, immunization affords extended protection.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE