Immunologic Interrelationships of Coliform Heat-Labile and Heat-Stable Enterotoxins
Rept. no. 7 (Annual) 15 Feb 1978-15 Jan 1979
ROCHESTER UNIV NY SCHOOL OF MEDICINE AND DENTISTRY
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The goal of these studies is the development of an immunization program to prevent diarrheal disease due to intestinal contamination by enterotoxigenic strains of coliform bacteria. We have demonstrated that a active immunization with a purified preparation of the polymyxin release form of Escherichia coli heat-labile enterotoxin yields protection against strains of this bacteria which produce this form of toxin b the use of cimetidine renders the peroral route of immunization effective and c peroral, but not parenteral, immunization affords extended protection.
- Medicine and Medical Research