Accession Number:

ADA065672

Title:

Cardio-Pulmonary Response to Shock.

Descriptive Note:

Annual process rept. 1 Feb-31 Aug 78,

Corporate Author:

HARVARD MEDICAL SCHOOL BOSTON MASS

Personal Author(s):

Report Date:

1978-08-01

Pagination or Media Count:

18.0

Abstract:

Pressure breathing and particularly PEEP were found to alter pulmonary metabolic activities. In animals treated with PEEP there was release of a humoral agent which decreased contractility plasminogen activator normally cleared by the lungs during spontaneous breathing was now secreted there was a decreased ability to clear barbiturates and lactate a selective red cell acidosis was induced during lactate infusion and systemic blood flow was redistributed. Metabolism was severely altered when a lung lobe was isolated and perfused from a support dog. A variety of negative inotropic agents were released which led to death of the support animal. These cardiac muscle studies were assisted by the development of a new, isolated papillary muscle chamber. Author

Subject Categories:

  • Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE