Cardio-Pulmonary Response to Shock.
Annual process rept. 1 Feb-31 Aug 78,
HARVARD MEDICAL SCHOOL BOSTON MASS
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Pressure breathing and particularly PEEP were found to alter pulmonary metabolic activities. In animals treated with PEEP there was release of a humoral agent which decreased contractility plasminogen activator normally cleared by the lungs during spontaneous breathing was now secreted there was a decreased ability to clear barbiturates and lactate a selective red cell acidosis was induced during lactate infusion and systemic blood flow was redistributed. Metabolism was severely altered when a lung lobe was isolated and perfused from a support dog. A variety of negative inotropic agents were released which led to death of the support animal. These cardiac muscle studies were assisted by the development of a new, isolated papillary muscle chamber. Author
- Anatomy and Physiology