Accession Number:
ADA065672
Title:
Cardio-Pulmonary Response to Shock.
Descriptive Note:
Annual process rept. 1 Feb-31 Aug 78,
Corporate Author:
HARVARD MEDICAL SCHOOL BOSTON MASS
Personal Author(s):
Report Date:
1978-08-01
Pagination or Media Count:
18.0
Abstract:
Pressure breathing and particularly PEEP were found to alter pulmonary metabolic activities. In animals treated with PEEP there was release of a humoral agent which decreased contractility plasminogen activator normally cleared by the lungs during spontaneous breathing was now secreted there was a decreased ability to clear barbiturates and lactate a selective red cell acidosis was induced during lactate infusion and systemic blood flow was redistributed. Metabolism was severely altered when a lung lobe was isolated and perfused from a support dog. A variety of negative inotropic agents were released which led to death of the support animal. These cardiac muscle studies were assisted by the development of a new, isolated papillary muscle chamber. Author
Subject Categories:
- Anatomy and Physiology