Cytochemistry of Malaria Under Treatment.
Annual rept. no. 8, 1 Jan-30 Sep 78,
CASE WESTERN RESERVE UNIV CLEVELAND OHIO INST OF PATHOLOGY
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Host-parasite interaction is of major importance to malarial parasites, since parasite survival depends on host cells. Studies on the interaction are essential for better understanding of malarial parasites. During the last fiscal year we have concentrated our investigation on several aspects of the interaction between malarial parasites and host cells, and established several new characteristics on the invasion process. Studies on the interaction are essential for better understanding of malarial parasites and host cells, and established several new characteristics on the invasion process. This study showed that invasion occurs through a sequence of events that include 1 recognition and attachment, 2 junction formation between the merozoite and host cell, 3 invagination of the erythrocyte membrane around the merozoite, and 4 sealing of the invaginated membrane to form a vacuole and to reestablish continuity of the erythrocyte membrane. The movement of the junction during invasion is an important component of the mechanism by which the merozoite enters the host cell. After completion of this work, we developed a method for blocking erythrocyte invasion by the merozoite at an early stage. Cytochalasin B-treated merozoites attached to host erythrocytes and then form a junction. However, cytochalasin blocked movement of the junction preventing further invasion. Author
- Medicine and Medical Research