Aerosol and Intramuscular Prophylaxis of Respiratory 'Klebsiella pneumoniae' Infection in Mice and Squirrel Monkeys.
ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FREDERICK MD
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Aerosol administration and intramuscular injection were compared for kanamycin prophylaxis against respiratory Klebsiella pneumoniae infection in both mice and squirrel monkeys. Mice challenged with an LD90 of Klebsiella 0.5, 4, 24, and 48 and 72 hours after aerosol treatment with 27 mgkg of kanamycin were significantly better protected at all time periods than were mice given 450 mgkg by IM injection. Squirrel monkeys given 11.25 mgkg by aerosol were completely protected against Klebsiella challenge at 6 and 24 hours whereas only 1 of 8 monkeys injected IM with the same dose survived at 6 hours and none survived at 24 hours. Antibiotic clearance curves suggested that kanamycin remained in the lungs at higher concentrations and for a longer time after aerosol than after IM treatment. Author