Comparative Biochemistry and Metabolism
Annual rept. 1 Jun 1977-31 May 1978
CALIFORNIA UNIV IRVINE
Pagination or Media Count:
Co-administration of an LDO.01 dose of hydrazine with 14C- methylmethionine to rats or mice results in the methylation at the 7-position of guanine in liver DNA in the mouse, but not in the rat, methylation at the O6 - position of guanine in liver DNA also occurs. Methylation of liver DNA in only the 7-position of guanine occurs in rats and mice treated with MMH and to a much lesser extent with UDMH. Carbon dioxide production from MMH and UDMH is most active in rat liver, less active in kidney and colon and only slightly active in lung carbon dioxide production from MMH is 1.4 to 5.5 times greater than for UDMH.