Accession Number:

ADA064955

Title:

Mutagen and Oncogen Study on RJ-4

Descriptive Note:

Final rept.

Corporate Author:

LITTON BIONETICS INC KENSINGTON MD

Personal Author(s):

Report Date:

1978-09-01

Pagination or Media Count:

59.0

Abstract:

The Material evaluated in this study was subjected to a matrix of in vitro assays employing microbial cells, mammalian cells in culture and in vivo tests measuring potential germ cell effects in mice and rats. RJ-4 did not produce results from the tests conducted which indicated that it has mutagenic properties. Results from a test for unscheduled DNA synthesis UDS in WI-38 cells, however, did indicate that RJ-4 was capable of interacting with DNA and could induce repairable DNA lesions. The fact that no mutagenic activity was detected in vitro or in vivo reduces the significance of the UDS results as an indication of potential risk. UDS activity alone is not sufficient to categorize RJ-4 as a mutagen but the results can be interpreted as indicating a nonspecific chemicalDNA interaction.

Subject Categories:

  • Medicine and Medical Research
  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE