Accession Number:

ADA064952

Title:

Mutagen and Oncogen Study on JP-4

Descriptive Note:

Final rept.

Corporate Author:

LITTON BIONETICS INC KENSINGTON MD

Personal Author(s):

Report Date:

1978-09-01

Pagination or Media Count:

59.0

Abstract:

The material evaluated in this study was subjected to a matrix of in vitro assays employing microbial cells, mammalian cells in culture and in vivo tests measuring potential germ cell effects in mice and rats. JP-4 was shown to induce nonspecific DNA damage in WI-38 cells and possibly preimplantation loss in rats. All other data from the test battery were negative. These results are not strong indications of human risk and could be considered as representing minimal genetic toxicity. Neither the unscheduled DNA synthesis or preimplantation loss are conclusive indicators of mutation. Their implications for potential carcinogenesis must also be considered weak in light of the majority of negative test data.

Subject Categories:

  • Medicine and Medical Research
  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE