Accession Number:

ADA064950

Title:

Mutagen and Oncogen Study on Triaminoguanidine Nitrate

Descriptive Note:

Final rept.

Corporate Author:

LITTON BIONETICS INC KENSINGTON MD

Personal Author(s):

Report Date:

1978-09-01

Pagination or Media Count:

59.0

Abstract:

The material evaluated in this study was subjected to a matrix of in vitro assays employing microbial cells, mammalian cells in culture and in vivo tests measuring potential germ cell effects in mice and rats. Triaminoguanidine nitrate TAGN was mutagenic and produced DNA damage in the in vitro assays. The response was obtained without the presence of an in vitro activation system, indicating that the TAGN molecule has genetic activity. No significant induction of dominant lethal effects was observed in either mice or rats. TAGN should be considered a suspect compound regarding mutagenic and carcinogenic potential. The combined positive results from all in vitro assays indicate a high level of probability for carcinogenic activity.

Subject Categories:

  • Medicine and Medical Research
  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE