Accession Number:

ADA064948

Title:

Mutagen and Oncogen Study on JP-8

Descriptive Note:

Final rept.

Corporate Author:

LITTON BIONETICS INC KENSINGTON MD

Personal Author(s):

Report Date:

1978-09-01

Pagination or Media Count:

59.0

Abstract:

The material evaluated in this study was subjected to a matrix of in vitro assays employing microbial cells, mammalian cells in culture and in vivo tests measuring potential germ cell effects in mice and rats. The test compound, JP-8 Tanic F-3, produced a moderate increase in unscheduled DNA synthesis in WI- 38 cells. These data suggest that the material could interact with DNA producting nonspecific lesions. No evidence for mutagenicity was evident in the test battery and the indications for mutagenic and carcinogenic potential for this compound are minimal at best. There is no suggestion of significant genetic risk associated with this material.

Subject Categories:

  • Medicine and Medical Research
  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE