Accession Number:

ADA064805

Title:

Prevention of Pulmonary Oxygen Toxicity.

Descriptive Note:

Final rept. 1971-1978,

Corporate Author:

SAINT VINCENT'S HOSPITAL AND MEDICAL CENTER OF NEW YORK DEPT OF PATHOLOGY

Report Date:

1978-01-01

Pagination or Media Count:

28.0

Abstract:

In view of the large number of patients and military personnel, who are or will be subjected to increased oxygen concentrations, determining the best way to prevent or to minimise oxygen toxicity or other attendant problems is quite important. This project focused on three areas a The main emphasis was on animal studies. An attempt was made to anticipate and resolve some of the problems which might be encountered clinically. These included alterations of microbial flora in upper respiratory tract. Rate of onset and the morphology of acute and chronic phase of pulmonary oxygen toxicity were studied. The optimal regimens for gradual adaptation to increased oxygen concentrations and the efficacy of the intermittent rest periods at lower oxygen concentrations were also determined. b Delivery of oxygen to the patients presents technical problems, including coping with iatrogenic damage to the airways. This portion of our study focused on delineation and reduction of such damage. c The usefulness of the research results, obtained by expenditure of ONR funds generated from tax revenues, is determined in part by the rapidity of information dissemination. This part of our project supplemented the publication route of informing the scientific community of the results of contract supported research by the use of lectures and scientific exhibits. This approach markedly enhanced the dissemination of our research findings.

Subject Categories:

  • Medicine and Medical Research
  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE