Alterations in Tissue Metabolism with Injury and Shock.
Annual summary rept. Oct 77-Nov 78,
YALE UNIV NEW HAVEN CONN SCHOOL OF MEDICINE
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Our studies have shown that infusion of ATP-MGCl2 following 60 to 90 minutes of hepatic ischemia improved hepatic function, cellular architecture and improved the survival of animals. To the best of our knowledge, this is the first demonstration that an agent has proved successful in the treatment of post-ischemic hepatic failure. Our results have also shown that infusion of ATP-MgCl2 following a severe renal insult significantly improved both glomerular and tubular function and preserved cellular structure. Thus, ATP-MgCl2 appears to enhance recovery from severe acute renal failure. These observations may have important implications for future use in organ preservation and management of post-ischemic acute renal failure. Our results also indicate that the accelerated recovery of post-ischemic acute renal failure by ATP-MgCl2 infusion could be due to provision of energy to ischemic kidneys thereby decreasing the severity of the nectotic lesion. Studies with sepsis have shown that infusion of ATP-MgCl2 plus glucose following severe spesis restored cellular ATP levels and reticuloendothelial system function and improved the survival of animals. Another study indicated that there was no change in arterial prostaglandin levels, however, renal vein samples did show a slight increase in prostaglandin E levels during hemorrhagic shock. In another area of research, we proposed that the activation of glucose transport by the enzyme trypsin takes place via the unmasking of the transport system through its proteolytic action while insulin exerts its metabolic effect through membrane conformation alterations. Author
- Anatomy and Physiology
- Medicine and Medical Research