Accession Number:

ADA064248

Title:

Synthesis of Antimalarial Agents from 2,3-Dihydro-1,6-diazaphenalene Derivatives.

Descriptive Note:

Annual rept. Oct 77-Dec 78,

Corporate Author:

WISCONSIN UNIV-MILWAUKEE DEPT OF CHEMISTRY

Personal Author(s):

Report Date:

1979-01-01

Pagination or Media Count:

46.0

Abstract:

The investigation to date has centered on construction of the 9H-1,6-diazaphenalene system and the more important 9-methoxy derivatives. By use of the oxime and Semmler Wolff approach outlined in our original proposal, the 1,6-diazaphenalone has been prepared, as well as the 5-amino quinoline derivative. In addition, work toward the 9-methoxy analogs has progressed quite well. Moreover, a two-step synthesis of dihydro-2,5-dihydroxy-1,6-diazaphenalene-1,6-dioxide has been developed. The Semmler Wolff product and the mono N-Oxide derivative of 26 have both been converted to 2,5-dichloro-1,6-diazaphenalene. Five systems will be converted to the diazaphenalene target compounds by standard methods during the second year.

Subject Categories:

  • Pharmacology
  • Organic Chemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE