Electrophysiological Determination of Retinal Sensitivity to Color After Intense Monochromatic Light Adaptation.
Final rept. Dec 75-Jan 77,
DUKE UNIV MEDICAL CENTER DURHAM N C DEPT OF OPHTHALMOLOGY
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The overall purpose of this research was to investigate a method for demonstrating changes in retinal ganglion-cell function after high-intensity radiation such as from a laser or other monochromatic source in the visible region. These experiments were designed to facilitate understanding functional retinal changes required to produce flash-blindness or permanent damage in human eyes, especially in the macular region which is so important in safety measures. Recordings were made from selected and well-characterized ganglion cells in animal retinas. Changes in receptive-field sensitivities were detected as a result of exposure to high-intensity monochromatic or broad-band light in part or all of the field. The time course of sensitivity recovery was also plotted. These results were then correlated with physiological and psychophysical data already known from other animal and human studies. The specific objective of this study was to delineate means by which ganglion cell responses could be used to evaluate color vision and visual-field loss after laser exposure of the monkey retina. Rabbit and cat retinas were used in developing the experimental techniques required for this evaluation. Author
- Anatomy and Physiology
- Lasers and Masers