Accession Number:

ADA063717

Title:

Evaluation of the Occupational Health Hazards of Nitroglycerin Using Mammalian Models

Descriptive Note:

Annual rept. 29 Jun 1976-30 Jun 1977

Corporate Author:

SRI INTERNATIONAL MENLO PARK CA

Personal Author(s):

Report Date:

1977-08-25

Pagination or Media Count:

37.0

Abstract:

A system was designed and constructed to allow monitoring of blood flow by the use of Doppler flow probes. The Doppler signals are transmitted via an implanted FM transmitter to an external receiver, where the signal is processed and transformed to calibrated flow on a strip-chart recorder. This technique was used to measure the effect of inhaled or percutaneously administered nitroglycerin on coronary blood flow in dogs. The results of the preliminary inhalation experiments indicate that the technique is valid for investigating whether nitroglycerin causes increased coronary artery blood flow and whether compensatory or reflex vasoconstriction occurs upon withdrawal. Both dogs exposed by inhalation seemed to demonstrate these phenomena slightly.

Subject Categories:

  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE